SURMOUNT-MAINTAIN randomized patients who had lost weight on the maximum dose of tirzepatide to either continue at full dose of 10 or 15 mg, reduce to 5 mg, or switch to placebo for an additional year
Other GLP-1 drugs such as Rybelsus, Ozempic, and Mounjaro are approved to treat Type 2 diabetes, but not for the treatment of weight-loss management, even though they have the same active ingredients
2013, doi: 10.1056/NEJMoa1215740
Third, the peptide's effects on growth factor signaling could theoretically interact with fibrotic processes, immunosuppressive therapy, or wound-healing pathways in post-surgical patients
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