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Mombeyni, A., Shakerian, S., Habibi, A
(2015) discovered that exendin-4 treatment in Glp1r+/+ mice elevated cAMP levels in isolated intraepithelial lymphocytes while reducing the transcription of multiple inflammatory mediators, including IL-1, IL-6, IL-22, IL-12, TNF-, CCL2, CXCL1, and CXCL2
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In a controlled trial, participants who consumed 12.5g of allulose showed higher GLP-1 levels and reduced hunger compared to a placebo group
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Taken together, LINA may increase USE by stimulating Nedd4-2-dependent ENaC ubiquitination via GLP-1-receptor axis-mediated reduction of 14-3-3 protein
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