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Phase 2 clinical data showed that starting at lower doses (1-2mg) partially mitigated gastrointestinal side effects compared to more aggressive starting doses

( I L ) GLP-1 or SS output (fmol/min) or mean incremental output (fmol/20 min) after luminal infusion of glucose in male Sstr5 / (blue) or Sstr5 +/+ mice (black) ( n = 5)

doi:10.1080/01480545.2018.1485687

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