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[21] [22] Patients with pre-existing gastroparesis or severe gastrointestinal disease were excluded from major clinical trials, and the FDA label specifically states that tirzepatide is not recommended in patients with severe gastrointestinal disease, including severe gastroparesis
However, once opened, the vial should be used within 28 days to maintain safety and efficacy, after which it should be discarded
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There could be a number of factors at work
The weight loss tends to be gradual and sustained, which is important for long-term health benefits and maintenance of results
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