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S-adenosylhomocysteine (SAH) but not lactate, taken upon patients inclusion in the study close to ICU admission, significantly and independently contributed to the prediction of disease progression and death [119] and SAM/SAH ratio was shown increased in a sepsis model in rats [125] as well as in human patients [120, 123]
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Standardized dosing protocols, validated outcome measures, and comprehensive safety monitoring would establish the evidence base necessary for informed clinical decision-making
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Research describes it as one of the body's central antioxidant molecules, studied for its role in pathways involved in oxidative-stress regulation and cellular redox balance
