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The trade-off is significant: 60-70% of the peptide is lost during nasal absorption, meaning you need 2-3 times the dose to achieve equivalent melanocortin receptor activation
doi: 10.1007/s00018-011-0633-6 214 BhushanBApteU
Pharmacol Rev 74:506551 Daneman R, Prat A (2015) The bloodbrain barrier
Another parent reported going from 6 umol/L to 30.5 umol/L in 3 months
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