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All participants had a diagnosis of ASD established with DSM-IV-TR or DSM-5 and validated with ADOS-2 and/or ADI-R, while individuals with neurological or psychiatric comorbidities, recent probiotic or oxytocin use, or unstable medications were excluded

However, if the ER stress is prolonged or excessive, ER UPR can ultimately lead to cell death via apoptotic pathways (115, 116)