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The specific outcomes evaluated across each of the studies can be grouped into the three major adverse cardiovascular events (MACE): cardiovascular death, nonfatal MI, and nonfatal stroke, progression of kidney disease, and heart failure hospitalizations
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Divalent metal transporter 1 (DMT1, also known as SLC11A2) mediates the release of Fe 2+ from endosomes into labile iron pools of the cytoplasm (Ke and Qian, 2007)
The phase 2 trial reported that GI events were the most common adverse effects across all dose groups, and they were dose-dependent, meaning they increased in frequency and severity as the dose went up
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