The medication works best when combined with lifestyle adjustments such as improved nutrition and increased physical activity
Understanding Side Effects and Management guide covers the timeline in more detail
Kaur I, Behl T, Aleya L, Rahman MH, Kumar A, Arora S, Akter R (2021) Role of metallic pollutants in neurodegeneration: effects of aluminum, lead, mercury, and arsenic in mediating brain impairment events and autism spectrum disorder
Particularly noteworthy were the marked differences in serious metabolic and renal complications: lactic acidosis (monotherapy: n = 15,789 vs combination: n = 567), acute kidney injury (7694 vs 675), diarrhea (6922 vs 3890), and metabolic acidosis (4713 vs 203)
doi: 10.1155/2017/8416763 171 AcevesCAnguianoBDelgadoG