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Stress: Chronic stress and elevated cortisol can interfere with growth hormone signaling

Tirzepatide is initiated at 2.5 mg subcutaneously once weekly for 4 weeks as a starting dose to improve gastrointestinal tolerability, then gradually titrated every 4 weeks up to a maximum of 15 mg weekly based on therapeutic response and tolerability

Expression of the SLC7A11 gene was compared between samples without mutation and samples with mutation

Even the review paper summarizing this study noted the results are not overly informative and reliable due to the lack of objective measures

Weight Loss: While weight loss can be a desirable outcome for many individuals with type 2 diabetes, excessive weight loss associated with GLP-1 medications may be problematic for some patients, especially those who are already at a healthy weight or at risk of malnutrition