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Next, we will summarize some promising medicine monomers that activate the GSH system based on the categories of natural medicines, including flavonoids, terpenoids, phenolic acids, quinones, and alkaloids (Table 2, Supplementary Table S2)

3-Indoleacetic acid is made from tryptophan by gut bacteria including Clostridia, reflecting how microbes handle this amino acid that also produces serotonin

Among GHS-R1a agonists, it has the most favorable selectivity profile: strong GH release, negligible cortisol stimulation, negligible prolactin stimulation, no meaningful ACTH effect [5]

These combination approaches are relevant to the retatrutide vs tirzepatide comparison because they represent alternative paths to multi-receptor weight loss therapy

Peng et al., 2023)