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This article reviews current evidence, evaluates pharmacological and mechanistic safety profiles, summarizes recent cohort studies, and discusses clinical management strategies for preconception counselling and inadvertent exposure

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Abbreviations CVD: Cardiovascular disease T2D: Type 2 diabetes CV: Cardiovascular HF: Heart failure GLP-1RA: Glucagon-like peptide 1 receptor agonist SGLT-2: Sodium-glucose cotransporter 2 MACE: Major cardiovascular events MI: Myocardial infarction ADA: American Diabetes Association HFrEF: Heart failure with reduced ejection fraction HFpEF: Heart failure with preserved ejection fraction FDA: Food and Drug Administration NHANES: National Health and Nutrition Examination Survey CKD: Chronic kidney disease References Grundy SM, Benjamin IJ, Burke GL, et al

The copper-bound complex delivers Cu to copper-dependent enzymes such as lysyl oxidase, which catalyzes collagen and elastin cross-linking

It supports injury recovery primarily by upregulating collagen and elastin synthesis, stimulating angiogenesis via VEGF and bFGF pathways, and broadly resetting gene expression in damaged tissue