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They are a supportive tool, not a standalone weight loss solution

In SURMOUNT-1, 72 weeks of tirzepatide induced mean WL of 1622.5% in people without diabetes compared to 2.4% with placebo, with no sign of the weight plateauing, suggesting that there may be further WL with long-term use [46]

It is recommended that adults over the age of 50 increase their sources of vitamin B12 through diet, fortified foods, B12 shots, or other supplements that can increase their B12 consumption. (By The National Institutes of Health) GASTROINTESTINAL ISSUES AND B12 SHOTS Persons who have gastrointestinal issues are particularly predisposed to issues with B12 deficiencies