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AARS1-mediated lactylation of H3K18 and STAT1 substantially triggers renal tubular cell ferroptosis by transcriptionally activating the lipid-elongating enzyme ELOVL5 ( + levels alongside GPX4 downregulation (92)

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Thus, high-tech surgical techniques are used, such as cross-linking, implantation of stromal rings, and keratoplasty in various modifications, which prevent further progression of clinical signs without eliminating the cause [3, 4]

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