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If retatrutide improves glycaemic control over time, this background risk may in fact be reduced rather than increased though this has not been specifically studied for retatrutide

Notably, the report suggested that semaglutide might improve obesity-associated subclinical neurodegeneration and might promote the regeneration of small corneal nerve fibers, indicating a potential neuroprotective effect during treatment

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Once prescribed, patients typically begin at the lowest dose and escalate over weeks per protocol, with regular follow-ups